RT info:eu-repo/semantics/article
T1 Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica
A1 Espinosa Cerrato, José
A1 Ráez Bravo, Arián
A1 López Olvera, Jorge Ramón
A1 Pérez, Jesús M.
A1 Lavín, Santiago
A1 Tvarijonaviciute, A.
A1 Cano Manuel, Francisco José
A1 Fandos, Paulino
A1 Soriguer, Ramón C.
A1 Granados, José Enrique
A1 Romero, Diego
A1 Velarde, Roser
A2 Sanidad Animal
K1 Sanidad animal
K1 Veterinaria
K1 Acetylcholinesterase
K1 Bacteria
K1 Lesion
K1 Mangy skin
K1 Non-dermal tissue
K1 Sarcoptic mange
K1 Serum amyloid a
K1 3109 Ciencias Veterinarias
AB [EN]Background: Sarcoptic mange has been identified as the most significant infectious disease affecting the Iberian ibex (Capra pyrenaica). Despite several studies on the effects of mange on ibex, the pathological and clinical picture derived from sarcoptic mange infestation is still poorly understood. To further knowledge of sarcoptic mange pathology, samples from ibex were evaluated from histological, microbiological and serological perspectives. Methods: Samples of skin, non-dermal tissues and blood were collected from 54 ibex (25 experimentally infected, 15 naturally infected and 14 healthy). Skin biopsies were examined at different stages of the disease for quantitative cellular, structural and vascular changes. Sixteen different non-dermal tissues of each ibex were taken for histological study. Acetylcholinesterase and serum amyloid A protein levels were evaluated from blood samples from ibex with different lesional grade. Samples of mangy skin, suppurative lesions and internal organs were characterized microbiologically by culture. Bacterial colonies were identified by a desorption/ionization time-of-flight mass spectrometry system (MALDI TOF/TOF). Results: The histological study of the skin lesions revealed serious acanthosis, hyperkeratosis, rete ridges, spongiotic oedema, serocellular and eosinophilic crusts, exocytosis foci, apoptotic cells and sebaceous gland hyperplasia. The cellular response in the dermis was consistent with type I and type IV hypersensitivity responses. The most prominent histological findings in non-dermal tissues were lymphoid hyperplasia, leukocytosis, congestion and the presence of amyloid deposits. The increase in serum concentrations of acetylcholinesterase and amyloid A protein correlated positively with the establishment of the inflammatory response in mangy skin and the presence of systemic amyloidosis. A wide variety of bacterial agents were isolated and the simultaneous presence of these in mangy skin, lymph nodes and internal organs such as lungs, liver, spleen and kidney was compatible with a septicaemic pattern of infection. Conclusions: The alteration of biomarkers of inflammation and its implication in the pathogenesis of the disease and development of lesions in non-dermal tissues and septicaemic processes are serious conditioners for the survival of the mangy ibex. This severe clinical picture could be an important factor when considering the decision to eliminate animals that exceed a certain disease threshold from a population.
PB BMC
LK https://hdl.handle.net/10612/19722
UL https://hdl.handle.net/10612/19722
NO Espinosa, J., Ráez-Bravo, A., López-Olvera, J. R., Pérez, J. M., Lavín, S., Tvarijonaviciute, A., Cano-Manuel, F. J., Fandos, P., Soriguer, R. C., Granados, J. E., Romero, D., & Velarde, R. (2017). Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica. Parasites and Vectors, 10, Article e596. https://doi.org/10.1186/S13071-017-2542-5
NO © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 02-jun-2024