RT info:eu-repo/semantics/article
T1 Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol
A1 García, Juan J.
A1 Fernández, Nélida
A1 Diez Liébana, María José
A1 Sahagún , Ana M.
A1 González, Aranzazu
A1 Alonso, M. Luisa
A1 Prieto, Carlos
A1 Calle Pardo, Ángela Pilar
A1 Sierra Vega, Matilde
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Ethinylestradiol
K1 Guar gum
K1 Psyllium
K1 Pharmacokinetics
K1 Fiber
K1 Rabbits
AB Dietary fibers are widely used in hypoglycaemic, hypolipidemic, slimming diets. It is probable that their ingestion coincides with the oraladministration of drugs and a modification of their pharmacokinetics can appear. In the present study, the influence of two soluble fibers(guar gum and psyllium) was evaluated on the pharmacokinetics of ethinyloestradiol (EE) when they were administered together to femalerabbits via the oral route. Three groups of rabbits were used. All animals received 1 mg/kg of EE; this compound was administered alonein the control group and with 3.5 g of guar gum or psyllium in the other two groups. When guar gum was administered, there was a decreasein the extent of EE absorbed, but no change was observed in the rate of absorption. When psyllium was administered, the extent of EEabsorbed increased slightly and the rate of absorption was slower.
PB ARHP
YR 2015
FD 2015-07-29
LK http://hdl.handle.net/10612/4443
UL http://hdl.handle.net/10612/4443
NO Contraception, 2000, n. 62
NO P. 253-257
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 05-jun-2024