RT info:eu-repo/semantics/article
T1 Pharmacokinetics of ethinyloestradiol in rabbits after intravenous administration
A1 Fernández, Nélida
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Terán Somaza, María Teresa
A1 Sahagún , Ana M.
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Veterinaria
K1 Ethinylestradiol
K1 Pharmacokinetics
K1 Itravenous administration
K1 Rabbits
K1 Oestrogens
AB The pharmacokinetics of ethinyloestradiol (EE 2) after intravenous administration of 30,50 and 100 µg.kg-1  was investigated in rabbits. A high-performance liquid chromatographic (HPLC) method with electrochemical (EC) detection was used to measure EE2 in plasma samples in order to avoid the interferences of natural oestrogens.After compartmental analysis, the disposition of EE2 was well described by a two-cpmpartmental open model with mean values of: α = 0.3448  ± 0.2922, 0.1965  ± 0.1755, 0.3058  ± 0.1225 m-1 and  β = 0.0137  ± 0.0018, 0.0140  ± 0.0065, 0.0198  ± 0.0066 min-1, for the three doses studied, respectively.There were no dose-related differences (ANOVA, P< 0.05) in a,b or Vss but significant differences were detected in clearance (90.9  ± 18.7; 80.6  ± 17.6; 116.3  ± 21.5 ml.min-1.Kg-1) between the 100 µg.kg-1  group and lower dose groups. The AUC increased significantly with the doses ( 341.7  ± 67.1; 645.8  ± 143.9; 892.2  ± 211.9 ng.min.ml-1). After non-compartmental analysis there were no significant differences in λ, MRT or Vss  as  a function of dose, but these differences were significant differences in AUC or CI values obtained by compartmental and non-compartmental analysis.
PB Elsevier
YR 2015
FD 2015-09-04
LK http://hdl.handle.net/10612/4577
UL http://hdl.handle.net/10612/4577
NO Contraception, 1996, n.53
NO P. 307-312
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 01-jun-2024