RT info:eu-repo/semantics/article
T1 A randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameters
A1 Fernández, Nélida
A1 Hernandez, Luis
A1 Sierra Vega, Matilde
A1 Diez Liébana, María José
A1 Calle Pardo, Ángela Pilar
A1 Carriedo, Demetrio
A1 Sahagún , Ana M.
A1 Anguera, Anna
A1 García, Juan J.
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Medicina. Salud
K1 Levodopa
K1 Parkinson patients
K1 Pharmacokinetics
K1 Biochemical parameters
K1 Plantago ovata husk
AB Background: Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce thesymptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopapharmacokinetics. The maintenance of constant plasma concentrations of levodopa abolishes the clinicalfluctuations in parkinsonian patients. The aim of this randomised clinical trial was to establish the influence of thefiber Plantago ovata husk in the pharmacokinetics of levodopa when administered to Parkinson patients wellcontrolled by their oral medication.Methods: To evaluate the effects of this fiber on several biochemical parameters. 18 volunteers participated inthe study and received alternatively two treatments (Plantago ovata husk or placebo) with their usuallevodopa/carbidopa oral dose. On days 0 (initial situation), 14 and 35 of the study, blood samples were taken toassess levodopa pharmacokinetics and to determine biochemical parameters.Results: Levodopa Cmax was very similar in the initial situation (603.2 ng/ml) and after placebo administration(612.0 ng/ml), being slightly lower (547.8 ng/ml) when Plantago ovata husk was given. AUC was very similar inthe three groups: initial situation.- 62.87 μg.min/ml, fiber treatment.- 64.47 μg.min/ml and placebo treatment.- 65.10μg.min/ml. Fiber reduced significantly the number of peaks observed in the levodopa concentrations, maintainingconcentrations more stable. No significant differences were found in total cholesterol, LDL-cholesterol and triglycerideswith the administration of Plantago ovata husk.Conclusions: Plantago ovata husk administration caused a smoothing and homogenization of levodopa absorption,providing more stable concentrations and final higher levels, resulting in a great benefit for patients.
PB Biomed central
YR 2015
FD 2015-10-21
LK http://hdl.handle.net/10612/4705
UL http://hdl.handle.net/10612/4705
NO BMC complementary and alternative medicine, 2014, n. 14
NO P. 296-305
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 03-jun-2024