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Título
The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
International Journal of Molecular Sciences
Cita Bibliográfica
Rodriguez-Barbosa, J.-I., Schneider, P., Graca, L., Bühler, L., Perez-Simon, J.-A., & Del Rio, M.-L. (2020). The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens [Review of The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens]. International Journal of Molecular Sciences, 21(9). MDPI AG. https://doi.org/10.3390/IJMS21093347
Editorial
MDPI
Fecha
2020
ISSN
1422-0067
Resumen
[EN] Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self
through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion
largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor
necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to
promote peripheral Tregs expansion and sustain their survival. This property can be leveraged to
enhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cells
during the course of immune reconstitution. This is of particular interest in peri-transplant tolerance
induction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cells
or in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioning
regimens are being implemented to limit long-term side effects of continuous immunosuppression and
facilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostatic
proliferation in response to cytoreductive conditioning is a window of opportunity to enhance
preferential expansion of Tregs during homeostatic proliferation that can be potentiated by agonist
stimulation of TNFR
Materia
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ID proyecto
- info:eu-repo/grantAgreement/ MINECO / Programa Estatal de I+D+I Orientada a los Retos de la Sociedad / PI13/00029 /ES/ Estudio de la interacción CD160/HVEM como diana para el control del rechazo mediado por linfocitos T CD8 y células NK en un biomodelo preclínico de aloreactividad
- info:eu-repo/grantAgreement/Junta de Castilla y León/ LE093U13 / ESTUDIO DE LAS INTERACCIONES DE CD160 CON SU RECEPTOR HVEM EN UN MODELO PRECLÍNICO DE ALOREACTIVIDAD QUE MIMETIZA LA ENFERMEDAD DE INJERTO FRENTE A HUÉSPED EN TRASPLANTE"
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DOI
Editorial
MDPI
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