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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Río González, María Luisa del | |
dc.contributor.author | Rodríguez Barbosa, José Ignacio | |
dc.contributor.author | Schneider, Pascal | |
dc.contributor.author | Graca, Luis | |
dc.contributor.author | Buhler, Leo | |
dc.contributor.author | Pérez-Simón, José-Antonio | |
dc.contributor.other | Inmunologia | es_ES |
dc.date | 2020 | |
dc.date.accessioned | 2024-01-16T08:30:16Z | |
dc.date.available | 2024-01-16T08:30:16Z | |
dc.identifier.citation | Rodriguez-Barbosa, J.-I., Schneider, P., Graca, L., Bühler, L., Perez-Simon, J.-A., & Del Rio, M.-L. (2020). The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens [Review of The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens]. International Journal of Molecular Sciences, 21(9). MDPI AG. https://doi.org/10.3390/IJMS21093347 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | https://hdl.handle.net/10612/17621 | |
dc.description.abstract | [EN] Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote peripheral Tregs expansion and sustain their survival. This property can be leveraged to enhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cells during the course of immune reconstitution. This is of particular interest in peri-transplant tolerance induction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cells or in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioning regimens are being implemented to limit long-term side effects of continuous immunosuppression and facilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostatic proliferation in response to cytoreductive conditioning is a window of opportunity to enhance preferential expansion of Tregs during homeostatic proliferation that can be potentiated by agonist stimulation of TNFR | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Inmunología | es_ES |
dc.subject.other | regulatory T cells | es_ES |
dc.subject.other | lymphopenia | es_ES |
dc.subject.other | homeostatic proliferation | es_ES |
dc.subject.other | transplantation | es_ES |
dc.subject.other | TNF/TNF receptors | es_ES |
dc.subject.other | graft-versus-host disease | es_ES |
dc.subject.other | graft rejection | es_ES |
dc.title | The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/IJMS21093347 | |
dc.relation.projectID | info:eu-repo/grantAgreement/ MINECO / Programa Estatal de I+D+I Orientada a los Retos de la Sociedad / PI13/00029 /ES/ Estudio de la interacción CD160/HVEM como diana para el control del rechazo mediado por linfocitos T CD8 y células NK en un biomodelo preclínico de aloreactividad | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Junta de Castilla y León/ LE093U13 / ESTUDIO DE LAS INTERACCIONES DE CD160 CON SU RECEPTOR HVEM EN UN MODELO PRECLÍNICO DE ALOREACTIVIDAD QUE MIMETIZA LA ENFERMEDAD DE INJERTO FRENTE A HUÉSPED EN TRASPLANTE" | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1422-0067 | |
dc.identifier.essn | 1661-6596 | |
dc.journal.title | International Journal of Molecular Sciences | |
dc.subject.unesco | inmunología | |
dc.audience.educationLevel | ||
dc.identifier.editorial | MDPI |
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