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    Título
    Transcriptomics of Haemophilus (Glässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
    Autor
    Álvarez Estrada, Álvaro
    Gutiérrez Martín, César BernardoAutoridad BuleriaORCID
    Rodríguez Ferri, Elías FernandoAutoridad BuleriaORCID
    Martínez Martínez, SoniaAutoridad BuleriaORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Datos de la obra
    BMC Veterinary Research, 2018, vol. 14 (1), Nov 6
    Editor
    Springer
    Fecha
    2018-11-06
    Abstract
    Haemophilus (Glässerella) parasuis is the etiological agent of Glässer’s disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly on the study of outer membrane proteins. This study investigates the transcriptome of H. (G.) parasuis serovar 5 subjected to in vitro conditions mimicking to those existing during an infection (high temperature and iron-restriction), with the aim of detecting the overexpression of genes coding proteins exposed on bacterial surface, which could represent good targets as vaccine candidates. The transcriptomic approach identified 13 upregulated genes coding surface proteins: TbpA, TbpB, HxuA, HxuB, HxuC, FhuA, FimD, TolC, an autotransporter, a protein with immunoglobulin folding domains, another large protein with a tetratricopeptide repeat and two small proteins that did not contain any known domains. Of these, the first six genes coded proteins being related to iron extraction. Six of the proteins have already been tested as vaccine antigens in murine and/or porcine infection models and showed protection against H. (G.) parasuis. However, the remaining seven have not yet been tested and, consequently, they could become useful as putative antigens in the prevention of Glässer’s disease. Anyway, the expression of this seven novel vaccine candidates should be shown in other serovars different from serovar 5.
    Materia
    Sanidad animal
    Veterinaria
    Palabras clave
    Haemophilus parasuis
    Glässer’s disease
    Ganado porcino
    Vacunas
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/10840
    Versión del editor
    https://doi.org/10.1186/s12917-018-1647-1
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