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    Citas

    Título
    Systemic and local immune responses in sheep after Neospora caninum experim infection at early, mid and late gestation
    Autor
    Arranz Solis, David
    Benavides Silván, Julio
    Regidor Cerrillo, Javier
    Horcajo Iglesias, María del Pilar
    Castaño Labajo, Pablo
    Ferreras Estrada, María Del CarmenAutoridad Buleria
    Jiménez Pelayo, Laura
    Collantes Fernández, Esther
    Ferré Pérez, Ignacio
    Hemphill, Andrew
    Pérez Pérez, ValentínAutoridad Buleria
    Ortega Mora, Luis Miguel
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Título de la revista
    Veterinary Research
    Número de la revista
    2
    Editor
    Springer
    Fecha
    2016-01-06
    ISSN
    0928-4249
    Abstract
    Besides its importance in cattle, Neospora caninum may also pose a high risk as abortifacient for small ruminants. We have recently demonstrated that the outcome of experimental infection of pregnant sheep with 106 Nc-Spain7 tachyzoites is strongly dependent on the time of gestation. In the current study, we assessed peripheral and local immune response in those animals. Serological analysis revealed earlier and higher IFN-γ and IgG responses in ewes infected at early (G1) and mid (G2) gestation, when abortion occurred. IL-4 was not detected in sera from any sheep. Inflammatory infiltrates in the placenta mainly consisted of CD8+ and, to a lesser extent, CD4+ T cells and macrophages (CD163+). The infiltrate was more intense in sheep infected at mid-gestation. In the foetal mesenchyme, mostly free tachyzoites were found in animals infected at G1, while those infected in G2 displayed predominantly particulate antigen, and parasitophorous vacuoles were detected in sheep infected at G3. A similar pattern of placental cytokine mRNA expression was found in all groups, displaying a strengthened upregulation of IFN-γ and IL-4 and milder increases of TNF-α and IL-10, reminiscent of a mixed Th1 and Th2 response. IL-12 and IL-6 were only slightly upregulated in G2, and TGF-β was downregulated in G1 and G2, suggestive of limited T regulatory (Treg) cell activity. No significant expression of TLR2 or TLR4 could be detected. In summary, this study confirms the pivotal role of systemic and local immune responses at different times of gestation during N. caninum infection in sheep.
    Materia
    Inmunología
    Veterinaria
    Palabras clave
    • Ganado ovino
    • Embarazo
    • Inmunología veterinaria
    • Neospora caninum
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/12291
    DOI
    10.1186/s13567‑015‑0290‑0
    Versión del editor
    https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-015-0290-0
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