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Título
Altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Food & Function
Cita Bibliográfica
García-Mateos, D., García-Villalba, R., Otero, J. A., Marañón, J. A., Espín, J. C., Álvarez, A. I., & Merino, G. (2018). An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice. Food and Function.
Editorial
Royal Society of Chemistry
Fecha
2018
ISSN
2042-6496
Resumen
Lignans are dietary polyphenols, which are metabolized by gut microbiota into the phytoestrogenic
metabolites enterolignans, mainly enterolactone and enterodiol. Breast Cancer Resistance Protein
(BCRP/ABCG2) is an efflux transporter that affects the plasma and milk secretion of several drugs and
natural compounds. We hypothesized here that Abcg2 could influence the levels of lignans and their
derived metabolites in target tissues. Consequently, we aimed to evaluate the role of Abcg2 in the
tissue distribution of these compounds. We used Abcg2−/− knockout and wild-type male mice fed with
a lignan-enriched diet for one week and analysed their plasma, small intestine, colon, liver, kidneys and
testicles. High levels of lignans as well as enterolignans and their glucuronide and sulfate conjugates in
the small intestine and colon were detected, with higher concentrations of the conjugates in the wildtype compared with Abcg2−/− mice. Particularly relevant was the detection of 24-fold and 8-fold
higher concentrations of enterolactone-sulfate and enterolactone-glucuronide, respectively, in the
kidney of Abcg2−/− compared with wild-type mice. In conclusion, our study showed that lignans and
their derived metabolites were in vivo substrates of Abcg2, which affected their plasma and tissue
levels. These results highlight the role of Abcg2 in influencing the health-beneficial properties of
dietary lignans.
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