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dc.contributor | Facultad de Ciencias de la Salud | es_ES |
dc.contributor.author | Seco Calvo, Jesús Ángel | |
dc.contributor.author | Sánchez Herráez, Sergio | |
dc.contributor.author | Casis, Luis | |
dc.contributor.author | Valdivia, Asier | |
dc.contributor.author | Pérez Urzelai, Itxaro | |
dc.contributor.author | Gil, Javier | |
dc.contributor.author | Echevarría, Enrique | |
dc.contributor.other | Fisioterapia | es_ES |
dc.date | 2020-11-02 | |
dc.date.accessioned | 2024-01-15T12:45:15Z | |
dc.date.available | 2024-01-15T12:45:15Z | |
dc.identifier.citation | Seco-Calvo, J., Sánchez-Herráez, S., Casis, L., Valdivia, A., Perez-Urzelai, I., Gil, J., & Echevarría, E. (2020). Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression. Bone & joint research, 9(11), 789–797. https://doi.org/10.1302/2046-3758.911.BJR-2020-0022.R2 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17617 | |
dc.description.abstract | [EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep- tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with dif- ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had signifi- cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of dis- ease burden and predictive biomarker of progression in KOA. | es_ES |
dc.language | eng | es_ES |
dc.publisher | The British Editorial Society of Bone & Joint Surgery, | es_ES |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | Synovial fluid | es_ES |
dc.subject.other | Peptidase activity | es_ES |
dc.subject.other | Knee osteoarthritis | es_ES |
dc.title | Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1302/2046-3758.911.BJR-2020-0022.R2 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2046-3758 | |
dc.journal.title | Bone & Joint Research | es_ES |
dc.volume.number | 9 | es_ES |
dc.issue.number | 11 | es_ES |
dc.page.initial | 789 | es_ES |
dc.page.final | 797 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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