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Título
Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Bone & Joint Research
Número de la revista
11
Cita Bibliográfica
Seco-Calvo, J., Sánchez-Herráez, S., Casis, L., Valdivia, A., Perez-Urzelai, I., Gil, J., & Echevarría, E. (2020). Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression. Bone & joint research, 9(11), 789–797. https://doi.org/10.1302/2046-3758.911.BJR-2020-0022.R2
Editorial
The British Editorial Society of Bone & Joint Surgery,
Fecha
2020-11-02
Resumen
[EN]
Aims
To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur-
den and predictive biomarker of progression in knee osteoarthritis (KOA).
Methods
A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years
(SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis)
recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario
de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep-
tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase
(PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl
aminopeptidase (PGAP).
results
Synovial fluid peptidase activity varied significantly as a function of clinical signs, with dif-
ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with
knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with
knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001)
with knee effusion. Further, patients with the greatest functional impairment had signifi-
cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020),
and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the
renin-angiotensin system. A binary logistic regression model showed that PSA was protective
(p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012).
Conclusion
These results suggest synovial fluid peptidase activity could play a role as a measure of dis-
ease burden and predictive biomarker of progression in KOA.
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