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Título
Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
mSystems
Número de la revista
3
Cita Bibliográfica
Del Carratore, F., Iorio, M., Pérez-Bonilla, M., Schmidt, K., Pérez-Redondo, R., Sosio, M., Macdonald, S. J., Gyulev, I. S., Tsigkinopoulou, A., Thomas, G. H., Genilloud, O., Rodríguez-García, A., Donadio, S., Breitling, R., & Takano, E. (2021). Multi-omics study of planobispora rosea, producer of the thiopeptide antibiotic GE2270A. mSystems, 6(3), Article e341. https://doi.org/10.1128/MSYSTEMS.00341-21
Editorial
American Society for Microbiology
Fecha
2021-06-22
Resumen
[EN] Planobispora rosea is the natural producer of the potent thiopeptide antibiotic GE2270A. Here, we present the results of a metabolomics and transcriptomics analysis of P. rosea during production of GE2270A. The data generated provides useful insights into the biology of this genetically intractable bacterium. We characterize the details of the shutdown of protein biosynthesis and the respiratory chain associated with the end of the exponential growth phase. We also provide the first description of the phosphate regulon in P. rosea. Based on the transcriptomics data, we show that both phosphate and iron are limiting P. rosea growth in our experimental conditions. Additionally, we identified and validated a new biosynthetic gene cluster associated with the production of the siderophores benarthin and dibenarthin in P. rosea. Together, the metabolomics and transcriptomics data are used to inform and refine the very first genome-scale metabolic model for P. rosea, which will be a valuable framework for the interpretation of future studies of the biology of this interesting but poorly characterized species
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/EC/H2020/720793/EU
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