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Título
Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Journal of Clinical Medicine
Número de la revista
9
Cita Bibliográfica
Farré, N., Mojón, D., Llagostera, M., Belarte-Tornero, L. C., Calvo-Fernández, A., Vallés, E., Negrete, A., García-Guimaraes, M., Bartolomé, Y., Fernández, C., García-Duran, A. B., Marrugat, J., and Vaquerizo, B. (2020). Prolonged qt interval in sars-cov-2 infection: Prevalence and prognosis. Journal of Clinical Medicine, 9(9), 1-15. https://doi.org/10.3390/JCM9092712
Editorial
MDPI
Fecha
2020-08-21
Resumen
[EN] Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is
not well known. Objective: To determine whether the presence of a prolonged QT on admission is
an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center
cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2,
recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within
the first 48 h after diagnosis and before the administration of any medication with a known effect on
QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval >480 milliseconds.
Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolonged
QTc and only 3.2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older,
had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes
of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was
higher in patients with prolonged QTc (41.0% vs. 8.7%, p < 0.001, multivariable HR 2.68 (1.58–4.55),
p < 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc
interval on admission. A prolonged QTc was independently associated with a higher mortality even
after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin.
An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients.
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