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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorBalseiro Morales, Ana María 
dc.contributor.authorAltuzarra, Raúl
dc.contributor.authorVidal, Enric
dc.contributor.authorMoll, Xavier
dc.contributor.authorEspada, Yvonne
dc.contributor.authorSevilla, Iker A.
dc.contributor.authorDomingo, Mariano
dc.contributor.authorGarrido, Joseba M.
dc.contributor.authorJuste, Ramón A.
dc.contributor.authorPrieto, Miguel
dc.contributor.authorPérez de Val, Bernat
dc.contributor.otherSanidad Animales_ES
dc.date2017
dc.date.accessioned2024-04-12T12:03:35Z
dc.date.available2024-04-12T12:03:35Z
dc.identifier.citationBalseiro, A., Altuzarra, R., Vidal, E., Moll, X., Espada, Y., Sevilla, I. A., Domingo, M., Garrido, J. M., Juste, R. A., Prieto, M., & Pérez de Val, B. (2017). Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep. PLoS ONE, 12(7), Article e0180546. https://doi.org/10.1371/JOURNAL.PONE.0180546es_ES
dc.identifier.otherhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180546es_ES
dc.identifier.urihttps://hdl.handle.net/10612/19718
dc.description.abstract[EN]Background/Aims: Animal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. The aims of this study were to develop an experimental TB infection model in sheep with a Mycobacterium caprae field strain isolated from a tuberculous diseased ewe, and to use this to evaluate the safety and efficacy of two vaccines against TB in sheep, the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. Methods: Eighteen 2 month-old lambs were experimentally challenged with M. caprae by the endotracheal route (1.5 × 103 CFU). They were separated per treatment group into parenterally vaccinated with a live BCG Danish strain vaccine (n = 6), orally vaccinated with a suspension of HIMB (n = 6) and unvaccinated controls (n = 6). Clinical, immunological, pathological and bacteriological parameters of infection were measured. Results: All lambs were successfully infected and developed gross TB lesions in the respiratory system. The BCG vaccine conferred considerable protection against experimental TB in lambs, as measured by a reduction of the gross lesion volumes and bacterial load. However, HIMB vaccinated animals did not show protection. Conclusions: This study proposes a reliable new experimental model for a better understanding of tuberculosis in sheep. BCG vaccination offers an effective prospect for controlling the disease. Moreover alternative doses and/or routes of administration should be considered to evaluate the efficacy of the HIMB vaccine candidate.es_ES
dc.languageenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSanidad animales_ES
dc.subjectVeterinariaes_ES
dc.subject.otherBCG vaccinees_ES
dc.subject.otherMycobacterium bovises_ES
dc.subject.otherVacunas (Veterinaria)es_ES
dc.subject.otherGanado ovinoes_ES
dc.titleAssessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheepes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1371/journal.pone.0180546
dc.description.peerreviewedSIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTA2014-00002-C02-01/ES/Estrategias de control de la tuberculosis bovina en reservorios silvestres (tejón y jabalí) y domésticos (ovino)es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1932-6203
dc.journal.titlePLOS ONEes_ES
dc.volume.number12es_ES
dc.issue.number7es_ES
dc.page.initiale0180546es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco3109 Ciencias Veterinariases_ES
dc.subject.unesco3104.07 Ovinoses_ES
dc.subject.unesco2412.10 Vacunases_ES
dc.description.projectWe are grateful to Albert Canturri (UAB), Maite Martín, Zoraida Cervera and the staff of the BSL-3 Unit of IRTA-CReSA for their technical support. We also thank Kevin P. Dalton for critically reviewing the manuscript. IRTA is supported by CERCA Programme / Generalitat de Catalunya.es_ES


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Atribución 4.0 Internacional
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