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Título
HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Cellular & Molecular Immunology
Número de la revista
7
Cita Bibliográfica
Rodríguez Barbosa, J. I., Schneider, P., Weigert, A., Lee, K.-M., Kim, T. J., Pérez Simón, J. A., & del Río, M. L. (2019). HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT. Cellular and Molecular Immunology, 16(7), 679-682. https://doi.org/10.1038/S41423-019-0241-1
Editorial
Nature
Fecha
2019
ISSN
1672-7681
Resumen
[EN] Temporal and spatial expression of cosignaling receptors and their
ligands regulates the early stages of T-cell activation (signal 1,
T-cell receptor (TCR) signaling and signal 2, costimulation/
coinhibition), clonal expansion and T-cell survival during their
differentiation towards effector T cells. Once the inflammatory
stimulus is eliminated, effector T cells return to homeostasis after
undergoing a contraction phase by activation-induced cell death
and the intervention of ligands for coinhibitory receptors, leaving
a population of long-term memory T cells. The expression of
ligands for coinhibitory receptors on hematopoietic cells and,
more importantly, on non-hematopoietic cells of peripheral
tissues is a key process in tuning the functional activity of effector
T cells to prevent excess tissue inflammation that may lead to
immunopathology and subsequent tissue dysfunction
Materia
Palabras clave
Peer review
SI
URI
DOI
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