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Título
Regulatory feedback loop between TP73 and TRIM32
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Cell Death & Disease
Datos de la obra
Gonzalez-Cano, L., Hillje, A.-L., Fuertes-Alvarez, S., Marques, M. M., Blanch, A., Ian, R. W., Irwin, M. S., Schwamborn, J. C. and Marín, M. C. (2013). Regulatory feedback loop between TP73 and TRIM32. Cell Death & Disease, 4, Article e704. https://doi.org/10.1038/cddis.2013.224
Editor
Springer Nature
Fecha
2013
Resumo
[EN] The p73 transcription factor is one of the members of the p53 family of tumor suppressors with unique biological functions in processes like neurogenesis, embryonic development and differentiation. For this reason, p73 activity is tightly regulated by multiple mechanisms, including transcription and post-translational modifications. Here, we identified a novel regulatory loop between TAp73 and the E3 ubiquitin ligase tripartite motif protein 32 (TRIM32). TRIM32, a new direct p73 transcriptional target in the context of neural progenitor cells, is differentially regulated by p73. Although TAp73 binds to the TRIM32 promoter and activates its expression, TAp73-induced TRIM32 expression is efficiently repressed by DNp73. TRIM32 in turn physically interacts with TAp73 and promotes its ubiquitination and degradation, impairing p73-dependent transcriptional activity. This mutual regulation between p73 and TRIM32 constitutes a novel feedback loop, which might have important implications in central nervous system development as well as relevance in oncogenesis, and thus emerges as a possible therapeutic target
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MICINN/Programa Nacional de Investigación Fundamental/SAF2009-07897/Identificación de las funciones del gen Tp73 en la biología de las células troncales hematopoyéticas y neurales
- info:eu-repo/grantAgreement/MICINN//SAF2012-36143
- info:eu-repo/grantAgreement/Junta de Castilla y León//LE015A10-2/fiEstudio de las funciones coordinadas de los supresores tumorales TP73 y TP53 en la biología de las células troncales neurales y su relevancia en envejecimiento y enfermedades neurodegenerativasfl
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