• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
Consorcio BUCLE Recolector
  • Contact Us
  • Send Feedback
  • Enlaces y accesos
    • Derechos de autor
    • Políticas
    • Guía de autoarchivo
    • FAQ y ayuda
    • La ULE y el Acceso Abierto
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Repositorio
    Institucional
    Abierto

    Consorcio BUCLE Recolector

    Browse

    All of BULERIACommunities and CollectionsAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulaciónThis CollectionAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulación

    My Account

    Login

    Statistics

    View Usage Statistics

    Otros enlaces

    View Item 
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item

    Compartir

    Export

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Título
    Microsomal enzyme induction by permethrin in rats
    Autor
    Anadón, A.
    Diez, M. José
    Sierra, MatildeAutoridad BuleriaORCID
    Sánchez, J. A.
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    Veterinary and Human toxicology, 1988, n. 45
    Editor
    Springer
    Fecha
    1988-03-03
    Abstract
    The synthetic pyrethroid, permethrin, was evaluated for its ability to alter hepatic microsomal drug-metabolizing function. The influence of permethrin (25:75 cis-trans) on plasma antipyrine kinetics and y-glutamyltranspepti dase (y-GTP) activity were studied in rats. After 3 days of administration of 90 mg permethrin/kg/day, there was no significant chage in the antipyrine half-life and the area under the curve, while the apparent volume of distribution and clearance were significantly increased. Tratment whith 190 mg permethrin/kg/day for 3 days decreased antipyrine half-life and the area under the curve, and incresed the apparent volume of distribution and the clearance sinificantly. The y-GTP activity was significantly incrased cithin 21 days and 14 days after the start of permethrin administration, at doses of 90 and 190 mg permethrin/kg/day, respectively. The antipyrine kinetics results indicate that permethrin is capable or producing a dose-dependent marked enzyme-inducing effect.
    Materia
    Ecología. Medio ambiente
    Farmacología
    Zoología
    Palabras clave
    Permethrin
    Ratas
    Enzyme
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4394
    Collections
    • Untitled [2723]
    Show full item record
    Files in this item
    Nombre:
    Veterinary and Human toxicology, 1988, p. 309-312
    Tamaño:
    3.961Mb
    Formato:
    Adobe PDF
    Thumbnail
    FilesOpen