Microsomal enzyme induction by permethrin in rats
Área de conocimiento
Datos de la obra
Veterinary and Human toxicology, 1988, n. 45
The synthetic pyrethroid, permethrin, was evaluated for its ability to alter hepatic microsomal drug-metabolizing function. The influence of permethrin (25:75 cis-trans) on plasma antipyrine kinetics and y-glutamyltranspepti dase (y-GTP) activity were studied in rats. After 3 days of administration of 90 mg permethrin/kg/day, there was no significant chage in the antipyrine half-life and the area under the curve, while the apparent volume of distribution and clearance were significantly increased. Tratment whith 190 mg permethrin/kg/day for 3 days decreased antipyrine half-life and the area under the curve, and incresed the apparent volume of distribution and the clearance sinificantly. The y-GTP activity was significantly incrased cithin 21 days and 14 days after the start of permethrin administration, at doses of 90 and 190 mg permethrin/kg/day, respectively. The antipyrine kinetics results indicate that permethrin is capable or producing a dose-dependent marked enzyme-inducing effect.