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    Título
    Effect of first-pass hepatic metabolism on the disposition of levamisole after intravenous administration in rabbits
    Autor
    Villanueva, Irma
    Diez, M. José
    García, Juan J.
    Fernández, Nélida
    Sahagún, Ana M.
    Sierra, Ana
    Sierra, Matilde
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    American journal of veterinary research, 2003, vol. 64, n. 10
    Editor
    American Veterinary Medical Assn.
    Fecha
    2003-04-03
    Descripción física
    P. 1283-1287
    Zusammenfassung
    To evaluate the contribution of first-pass hepatic metabolism of levamisole on levamisole disposition in rabbits. 30 male New Zealand white rabbits. Rabbits were randomly place into 2 groups. Rabbits in the first group received levamisole via the marginal ear vein at the following 3 doses: 12.5, 16, and 20mg/Kg (5 rabbits for each dose). Rabbits of the second group received levamisole via the jejunal vein at the same doses (5 rabbits each). During the following 240 minute period, plasma samples were obtained and quantified for levamisole concentrations by reversed-phase high-performace liquid chromatography. No significant differences were found between pharmacokinetic parameters calculated by compartmental or noncompartmental analysis. Mean hepoatic extraction ratio ranged from 0.044 to 0.017 and from 0.020 to 0.081 when area under the plasma concentration-time curve values were obtained after compartmental or noncompartmental analysis, respectively. After compartmental analysis, plasma concentration decreased bi-exponentially. Mean pharmacokinetic parameter values were as follows for each dose ( 12.5, 16, and 20 mg/Kg, respectively): after levamisole administration via the marginal ear vein, volume of distribution at steady state (Vss)= 4.26, 4.33, and 3.20 L/Kg; total body clearance (Cl) = 49.04,43.77 and 39.26 mL/Kg*min; and half-life associated with β-phase (t,1/2β)= 77.93, 85.39, and 69.79 minutes. After levamisole administration vea the jejunal vein, Vss = 4.38, 2.85, and 2.97 L/Kg, Cl= 48.14, 42.40, and 39.69 mL/Kg*min; and t1/2b = 101.9, 76.71, and 76.13 minutes. Levamisole has a low degree of hepatic extraction in rabbits
    Materia
    Farmacología
    Zoología
    Palabras clave
    Levamisol
    Pharmacokinetics
    Hepatic metabolism
    Rabbits
    Idioma
    eng
    Tipo documental
    info:eu-repo/semantics/article
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4554
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    American journal of veterinary research, 2003, p. 1283-1287
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