• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
  • Contact Us
  • Send Feedback
  • Enlaces y accesos
    • Derechos de autor
    • Políticas
    • Guía de autoarchivo
    • FAQ y ayuda
    • La ULE y el Acceso Abierto
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Repositorio
    Institucional
    Abierto

    Browse

    All of BULERIACommunities and CollectionsAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulaciónThis CollectionAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulación

    My Account

    Login

    Statistics

    View Usage Statistics

    Otros enlaces

    View Item 
    •   BULERIA Home
    • Scientific Production
    • Artículos de revista (post-print)
    • View Item
    •   BULERIA Home
    • Scientific Production
    • Artículos de revista (post-print)
    • View Item

    Compartir

    Export

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Academic Search
    Título
    Pharmacokinetics of a novel formulation of ivermecti n after administration to goats
    Autor
    González, Aranzazu
    Sahagún, Ana M.
    Diez, M. José
    Fernández, Nélida
    Sierra, MatildeAutoridad Buleria ORCID
    García, Juan J.
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    American Journal of Veterinary Research, 2006, vol. 67, n. 2
    Editor
    American Veterinary Medical Assn.
    Fecha
    2006-02-20
    Descripción física
    P. 323-328
    Abstract
    Objective-To evaluate the pharmacokinetics of a novel commercial formulation of ivermectin after administration to goats . Animals-6 healthy adult goats. Procedure-lvermectin (200 µg/kg) was initially administered IV to each goat, and plasma samples were obtained for 36 days. After a washout period of 3 weeks, each goat received a novel commercial for­ mulation of ivermectin (200 µg/kg) by se injection. Plasma samples were then obtained for 42 days. Drug concentrations were quantified by use of high­ performance liquid chromatography with fluores­ cence detection. Results-Pharmacokinetics of ivermectin after IV administration were best described by a 2-compart­ ment open model; values for main compartmental variables included volume of distribution at a steady state (9.94 L/kg), clearance (1.54 L/kg/d), and area under the plasma concentration-time curve (AUC; 143 [ng•dl/ml) . Values for the noncompartmental variables included mean residence time (7.37 days). AUe (153 [ng•dl/ml). and clearance (1.43 L/kg/d). After se administration, noncompartmental pharma­ cokinetic analysis was conducted . Values of the vari­ ables calculated by use of this method included max­ imum plasma concentration (Cmax; 21.8 ng/ml), time to reach Cmax (3 days). and bioavailability (F; 91.8%) . Conclusions and Clinical Relevance-The commer­ cial formulation used in this study is a good option to consider when administering ivermectin to goats because of the high absorption, which is character­ ized by high values of F. In addition, the values of Cmax and time to reach Cmax are higher than those reported by other investigators who used other routes of administration.
    Materia
    Farmacología
    Medicina. Salud
    Palabras clave
    Pharmacokinetics
    Ivermectin
    Goats
    Idioma
    eng
    Tipo documental
    info:eu-repo/semantics/article
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4565
    Collections
    • Artículos de revista (post-print) [2096]
    Show full item record
    Files in this item
    Nombre:
    American Journal of Veterinary Research, 2006, p. 323-328
    Tamaño:
    12.52Mb
    Formato:
    Adobe PDF
    Thumbnail
    FilesOpen