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    Título
    Pharmacokinetics of ethinyloestradiol in rabbits after intravenous administration
    Autor
    Fernández, Nélida
    Sierra, MatildeAutoridad BuleriaORCID
    Diez, M. José
    Terán, M. TeresaAutoridad Buleria
    Sahagún, Ana M.
    García, Juan J.
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    Contraception, 1996, n.53
    Editor
    Elsevier
    Fecha
    1996-09-25
    Abstract
    The pharmacokinetics of ethinyloestradiol (EE 2) after intravenous administration of 30,50 and 100 µg.kg-1 was investigated in rabbits. A high-performance liquid chromatographic (HPLC) method with electrochemical (EC) detection was used to measure EE2 in plasma samples in order to avoid the interferences of natural oestrogens. After compartmental analysis, the disposition of EE2 was well described by a two-cpmpartmental open model with mean values of: α = 0.3448 ± 0.2922, 0.1965 ± 0.1755, 0.3058 ± 0.1225 m-1 and β = 0.0137 ± 0.0018, 0.0140 ± 0.0065, 0.0198 ± 0.0066 min-1, for the three doses studied, respectively. There were no dose-related differences (ANOVA, P< 0.05) in a,b or Vss but significant differences were detected in clearance (90.9 ± 18.7; 80.6 ± 17.6; 116.3 ± 21.5 ml.min-1.Kg-1) between the 100 µg.kg-1 group and lower dose groups. The AUC increased significantly with the doses ( 341.7 ± 67.1; 645.8 ± 143.9; 892.2 ± 211.9 ng.min.ml-1). After non-compartmental analysis there were no significant differences in λ, MRT or Vss as a function of dose, but these differences were significant differences in AUC or CI values obtained by compartmental and non-compartmental analysis.
    Materia
    Ecología. Medio ambiente
    Farmacología
    Veterinaria
    Palabras clave
    Ethinylestradiol
    Pharmacokinetics
    Itravenous administration
    Rabbits
    Oestrogens
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4577
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    Contraception, 1996, p. 307-312
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