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Título
PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Transplant International
Datos de la obra
del Río, M. L., Buhler, L., Gibbons, C., Tian, J., & Rodríguez Barbosa, J. I. (2008). PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 21(11), 1015–1028. https://doi.org/10.1111/j.1432-2277.2008.00726.x
Editor
Frontiers Media
Fecha
2008
ISSN
0934-0874
Abstract
[EN] Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins
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