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    Título
    Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution
    Autor
    Castaño Labajo, Pablo
    Fuertes Franco, Miguel
    Regidor Cerrillo, Javier
    Ferré Pérez, Ignacio
    Fernández Fernández, Miguel
    Ferreras Estrada, María Del Carmen
    Moreno Gonzalo, Javier
    González Lanza, María del Camino
    Pereira Bueno, Juana María
    Katzer, Frank
    Ortega Mora, Luis Miguel
    Pérez Pérez, ValentínAutoridad Buleria
    Benavides Silván, Julio
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Título de la revista
    Veterinary Research
    Número de la revista
    43
    Editor
    Springer
    Fecha
    2016-03-16
    ISSN
    0928-4249
    Abstract
    The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.
    Materia
    Veterinaria
    Palabras clave
    Ganado ovino
    Toxoplasmosis
    Embarazo
    Parásitos
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/12292
    DOI
    https://doi.org/10.1186/s13567-016-0327-z
    Versión del editor
    https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-z
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