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Título
Impact of a COVID-19 Outbreak in an Elderly Care Home after Primary Vaccination
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Vaccines
Número de la revista
8
Cita Bibliográfica
Mauriz, E., Fernández-Vázquez, J. P., Díez-Flecha, C., Reguero-Celada, S., Fernández-Villa, T., Fernández-Somoano, A., Caylà, J. A., Lozano-García, J. A., Vázquez-Casares, A. M., & Martín-Sánchez, V. (2023). Impact of a COVID-19 Outbreak in an Elderly Care Home after Primary Vaccination. Vaccines, 11(8). https://doi.org/10.3390/VACCINES11081382
Editorial
MDPI
Fecha
2023
ISSN
2076-393X
Resumen
[EN] Elderly care home residents are particularly vulnerable to COVID-19 due to immunesenescence, pre-existing medical conditions, and the risk of transmission from staff and visitors.
This study aimed to describe the outcomes of a COVID-19 outbreak in a long-term care facility
for elderly persons following the initial vaccination. A single-center, retrospective, observational
design was used to analyze the variables associated with hospitalization and death rate by logistic
regression. Adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were calculated.
Sixty-eight residents received the first dose of the COVID-19 vaccine. Despite being negative six days
after vaccination, the performance of a second test 4 days later revealed 51 positives (75.0%) among
residents and 18 among workers (56.3%). A total of 65 of the 68 residents (95.58%) had positive
results with symptoms, whereas 34.9% required hospitalization, and 25.8% died. The best-fitting
model to explain the distribution of cases reflects three points at the time of infection.. The time
from vaccination to symptom onset explains the hospitalization and mortality rates since a day
elapsed halves the risk of hospitalization (aOR = 0.57; CI = 0.38−0.75) and the risk of death by a
quarter (aOR = 0.74; CI = 0.63−0.88). Nursing homes present an elevated risk of transmission and
severity of SARS-CoV-2 infection. Although vaccination reduces the risk of hospitalization and
death, extreme prevention and control measures are essential in these institutions despite the high
vaccination coverage.
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