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    Título
    Acute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer’s disease
    Autor
    Martínez Martínez, SoniaAutoridad Buleria ORCID
    Frandoloso, Rafael
    Gutiérrez Martín, César BernardoAutoridad Buleria ORCID
    Lampreave, Fermín
    García-Iglesias, María-José
    Pérez Martínez, ClaudiaAutoridad Buleria ORCID
    Rodríguez Ferri, Elías FernandoAutoridad Buleria ORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Datos de la obra
    Veterinary Immunology and Immunopathology, 2011
    Editor
    Elsevier
    Fecha
    2011-11-23
    Descripción física
    8 p.
    Abstract
    Haemophilus parasuis is the etiological agent of Glässer’s disease, which is characterized by fibrinous polyserositis, polyarthritis and meningitis in pigs. This study was focused on the characterization of the acute-phase response after immunization and infection of colostrum-deprived pigs with H. parasuis serovar 5, by measuring serum concentrations of three positive acute-phase proteins (APPs) (pig major acute-phase protein pig, MAP; haptoglobin, HPG; C-reactive protein, CRP) and one negative APP (apolipoprotein A-I, ApoA-I). Six experimental groups were established: a non-immunized but infected control group (CTL); two groups immunized with either a recombinant transferrin-binding protein (Tbp) A or TbpB fragment from H. parasuis Nagasaki strain (rTbpA and rTbpB, respectively); two groups immunized with native outer membrane proteins with affinity to porcine transferrin (NPAPT), one of them inoculated intramuscularly (NPAPTim) and the other intratracheally (NPAPTit), and the last group receiving a commercially available bacterin (PG). The greatest concentrations of the three positive APPs and the lowest concentration of the negative APP were detected in CTL group, as well as in those animals belonging to rTbpA or rTbpB groups that died in response to challenge. Significant differences (P < 0.005) were found in these groups when comparing challenge with the following days after it. However, no significant differences were seen for the remaining vaccinated groups (NPAPTim, NPAPTit and PG), which were effectively protected against Glässer’s disease. Therefore, APPs could be used as useful biomarkers for both evaluating disease progression and determining vaccination effectiveness
    Materia
    Sanidad animal
    Veterinaria
    Palabras clave
    Acute-phase proteins
    Haemophilus parasuis
    Glässer’s disease
    Idioma
    eng
    Tipo documental
    info:eu-repo/semantics/article
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/6471
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    • Artículos de revista (post-print) [2172]
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