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    Citas

    Título
    A vaccine based on a mutant transferrin binding protein B of Haemophilus parasuis induces a strong T-helper 2 response and bacterial clearance after experimental infection
    Autor
    Martínez Martínez, SoniaAutoridad BuleriaORCID
    Frandoloso, Rafael
    Rodríguez Ferri, Elías FernandoAutoridad BuleriaORCID
    García-Iglesias, María-José
    Pérez Martínez, ClaudiaAutoridad BuleriaORCID
    Álvarez Estrada, Álvaro
    Gutiérrez Martín, César BernardoAutoridad BuleriaORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Datos de la obra
    Veterinary Immunology and Immunopathology, 2016
    Editor
    Elsevier
    Fecha
    2016-07-23
    Abstract
    This study aimed to characterize the type of immune response induced by an experimental vaccine based on a mutant Haemophilus parasuis transferrin binding protein (Tbp) B (Y167A) defective in its ability to bind porcine transferrin. Clinical and pathological signs, bacterial clearance, antibody response and the cytokine profile in alveolar macrophages and spleen after the vaccination and challenge of twenty-two colostrum-deprived pigs with 108 CFU of H. parasuis were analysed. Pigs vaccinated with Y167A were compared to those vaccinated with native TbpB (nTbpB), those treated with a commercial bacterin (CB) against Glässer's disease, those unvaccinated challenged (CH) and those unvaccinated unchallenged (UNCH) pigs. The rectal temperatures of Y167A pigs resembled those of UNCH pigs and were significantly lower than those of the nTbpB, CB and CH animals. A major reduction in pathological changes of the challenged pigs was observed in the Y167A group. H. parasuis was cleared from 88.9% of the samples from Y167A pigs versus 60.0% and 55.6% from those of the CB and nTbpB groups, respectively. The antibody response elicited by Y167A by ELISA was notably higher than that observed for nTbpB and CB pigs and was capable of preventing the expression and secretion of IL-8. The expression of IL-4 and IL-5, which were associated with the specific antibody levels, suggests that the main mechanism of protection conferred by Y167A vaccine is based on a strong T-helper 2 response
    Materia
    Sanidad animal
    Palabras clave
    Haemophilus parasuis
    Glässer's disease
    Mutant TbpB vaccine
    Bacterias
    Antibodies
    Cytokines
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/6816
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